Encodes diamine oxidase, an enzyme involved in breaking down histamine and other amines. DAO is used here as an enzyme nickname; it is also the official symbol of a different gene.
Also called: DAO, Amine Oxidase, Copper Containing 1, Diami…
APOE encodes a protein that carries lipids between cells. The familiar APOE e2, e3 and e4 groupings depend on the combination of rs429358 and rs7412, not on either marker read in isolation.
Also called: Apolipoprotein E
Lipid transport and …
ATG16L1 is involved in autophagy, a process that helps cells recycle parts.
Also called: Autophagy-Related 16-Like 1
Cellular recycling meets gut immunity
ATG16L1 is involved in autophagy, a process that helps cells recycle parts. It is stu…
BHMT helps recycle homocysteine into methionine using betaine. It is a different route from the folate and B12 pathway.
Also called: BHMT08, Betaine-Homocysteine S-Methyltransferase
Another route through the homocysteine map
BHMT is part of…
COL5A1 encodes one component of type V collagen, which helps organize collagen fibers. It connects to the strength and structure of tendons, skin and other connective tissues.
Also called: Collagen Type V Alpha 1 Chain
Collagen structure, t…
The older Purser genetics reference uses the heading “DAOA (AOC1)” in its gut section.
Also called: D-Amino Acid Oxidase Activator
Two similar names, two different pathways
You may see DAOA and AOC1 written together in older materials, but …
FOLH1 helps break down folate from food so it can be absorbed. This is different from the MTHFR step.
Also called: Folate Hydrolase 1
Folate handling begins before remethylation
Dr. Purser’s genetic chapters include FOLH1 in folate handling…
FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier.
Also called: Folate Receptor …
FUT2 affects substances on the surfaces of the gut and other moist tissues and is studied in relation to the microbiome.
Also called: Fucosyltransferase 2
The mucosal and microbiome connection
Dr. Purser’s course places FUT2 in its gut–immu…
G6PC2 encodes a glucose-6-phosphatase-related protein expressed in pancreatic islet cells. Common variation is associated with differences in fasting glucose regulation; it is not the insulin receptor.
Also called: Glucose-6-Phosphatase Cat…
GAD1 helps your body make GABA, a chemical messenger, from glutamate.
Also called: Glutamate Decarboxylase 1
The glutamate-to-GABA connection
Dr. Purser’s course uses GAD/GABA teaching to explain a connection between excitatory and inhibito…
GSR encodes glutathione reductase. It uses reducing power from NADPH to help convert oxidized glutathione back to reduced glutathione, allowing this antioxidant system to be reused.
Also called: Glutathione Reductase
Recycling used glutathi…
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