MTHFR and ATP - the energy coin of our cells - have a very specific relationship. When you can’t methylate folate correclty, it leads to downstream effects of poor carbohydrate metabolism. When you should be making 32 ATP per carb, you may
MTHFR cuases a massive decrease in ATP PRODUCTION. This is why you’re TIRED ALL THE TIME. You literally can never get agead becuase you’re not metabolizing folate correctly. Now, let’s work through the methylation cycle and fill in the hole
Your fatigue never seems to end, but why is that? At the most basic cellular level you are not creating enough ATP causing your whole organism, your body, to have to compensate any way it can. This in turn makes you SO TIRED, never able to
At a cellular level, what does MTHFR really look like? A lack of energy production. The processes of creating ATP from carbohydrates is significantly reduced due to MTHFR SNPs, causing an overall fatigue for the person.
BUT, you can addre
ATP and MTHFR are closely correlated. If you cannot process folate and other B vitamins, you’re going to be tired due to inefficient ATP production. This causes chronic fatigue and other symptoms. So make sure to take your MTHFR Renew and M
How to produce more ATP with MTHFR? How to stop the unending fatigue that comes from low ATP caused by MTHFR? You have to get to the root, the intracellular levels of key vitamins and minerals that support the folate methylation cycle. Fill
MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets
If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.”
In this video, we break down exactly why this happens:
How MTHFR/methylation issues impair ATP (energy) production at the cellular level
Why your body desperately reaches for quick glucose
The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage
The downstream effects on antioxidants, DNA repair, and overall energy
How to finally break the cycle:
Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests)
Why our MTHFR Daily multivitamin was specifically formulated for this
The power of CMA intracellular testing
Intermittent fasting (12–16 hrs)
Fasted cardio (even just a brisk walk)
High-protein, real-food diet with minimal processed sugars
If you’re tired of the sugar rollercoaster and want stable energy, this is for you.
Links:
Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle
Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com
Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily
Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious!
#MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting
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Dr. Purser explains the diagnosis and treatment of MTHFR (methylenteterahydrofolate reductase enzyme deficiency disease). Learn the genetic component of this illness (such as C677T or A1298C) and how it affects the body's inability of methylation to convert carbohydrates into ATP (Adenosine Triphosphate). Discover how the complex enzyme pathways of the Krebs cycle and citric acid cycle convert carbohydrate molecules into ATP molecules in the mitochondria. Explore the relationship of MTHFR to vitamin and hormone deficiencies while understanding how vitamin supplements can replace key missing (u
Your fatigue is coming from deep in your cells, malnourishment that causes a lack of energy production at a cellular level.
The effeciency of Carbohdrate to ATP production is severely lacking if you have MTHFR Variants. Depending on how m
Well, let’s talk about how to deal with your MTHFR. Methylation of folate is your key problem here. Not processing folate correctly leads to CHRONIC FATIGUE, never being able to make enough ATP.
This is why you’re tired all the time, why
What does MTHFR really do to you? It makes you CONSTANTLY FATIGUED! You can never get ahead because you can’t create enough ATP in your cells. So, plug the holes and fet ENERGIZED! MTHFR is something you can deal with and feel great!
Get
Trying to kick that fatigue? There may be a genetic reason you’re not able to get over it. MTHFR is a real problem for a HUGE portion of the population. Methylation errors don’t allow you to produce enough ATP, causing you to always be behi
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