THE PURSER WELLNESS ENCYCLOPEDIA

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A RELATED COURSEHomocysteine: follow the connections

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Gene referenceSep 23, 2026

MTHFR

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Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.

Health BlogMar 13, 2026

The Hidden Molecule Driving Inflammation: Understanding the Purser Model of Homocysteine

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Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho

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