Let’s explore “HMGB1 & danger signals”

Explore Toll-like receptor 2, microbial and damage signals, TLR1, TLR6, and MyD88 signaling.

Explore skin inflammation, dermal collagen, granulomas, and related immune signals.

Explore Toll-like receptor 4, lipopolysaccharide (LPS), HMGB1, innate immune sensing, and related inflammatory pathways.

PURSER WELLNESSCope with Homocysteine Like a Pro!A conversation with Dr. Purser

High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy

Meet the immune signals IL-8 and MCP-1 and the research question linking them to homocysteine.

Follow the questions linking symptoms, genetics, homocysteine, and immune signals.

PURSER WELLNESSPurser Wellness Open House Livestream Recap: Root-Cause Medicine, Breakthroughs in Inflammation & RA conversation with Dr. Purser

…ncy to try to correct it right away. And so that that's the danger of that is you're doing too much. Yeah. So you feel you feel good the first week or 10 days and then all of a sudden you crash again. Yeah. That's when the methylation just …

PURSER WELLNESSPurser Wellness Open House | Livestream with Dan Purser MD and Team!A conversation with Dr. Purser

…ency to try to correct it right away and so that That's the danger of that is you're doing too much. Yeah. Goes slowilation. So you feel you feel good the first week or 10 days and then all of a sudden you crash again. That's when the methy…

…tigue, and brain fog can arise from many conditions. Immune signals such as TNF-alpha and IL-6 are relevant to some inflammatory illnesses, but symptoms alone cannot identify the cause. Follow the pathway Dr. Purser explains the relationsh…

…ects epithelial injury, fibroblasts, TGF-beta, inflammatory signals, and oxidative stress with scar formation. He discusses the difference between reducing inflammation and treating a fibrotic process; antioxidant mechanisms do not prove re…

… pigment-producing melanocytes in areas of the skin. Immune signals can help recruit and maintain cells that participate in this process. Follow the pathway Dr. Purser follows the IFN-gamma pathway through CXCL9 and CXCL10, which guide imm…

…lin. After insulin binds, the receptor activates a chain of signals that influences glucose uptake and metabolism. Follow the pathway Dr. Purser follows the receptor through IRS proteins, PI3K/AKT, and glucose transport. He discusses magne…