…ation toward cysteine-related chemistry. Folate/B12 and MTR/MTRR belong in the first discussion; CBS/CTH and glutathione-building materials belong in the second. MTHFR is an important piece, but not the entire map.
Putting the pieces togeth…
…elf.
Folate route
Helps recycle homocysteine
MTHFR · MTR · MTRR
Folate · B12 · B2
Folate and B12 connect to the route that recycles homocysteine back to methionine.
MTHFR helps produce 5-MTHF. MTR uses that folate-derived methyl group and …
…mocysteine Panel (not just MTHFR C677T/A1298C—includes MTR, MTRR, CBS, PEMT, etc.). Most labs stop at two SNPs. I test 22 because real patients have compound defects. Intracellular Micronutrient Testing to catch functional folate, B12, B6, …
…, and can raise blood pressure. Six genetic SNPs (like MTR, MTRR, and CBS) and MTHFR mutations (like C677T) can prevent homocysteine from converting into glutathione, which is essential for keeping inflammation in check. Plus, 12 vitamin de…
…are the major culprits:
1. MTHFR C677T & A1298C
2. MTR & MTRR
3. GGH
4. CBS (a tricky one—nobody likes this!)
Homozygous versions of these SNPs can shut down your methylation cycle, making it difficult for your body to manage homocyst…
…
Topics: homocysteine, MTHFR, C677T, A1298C, CBS, GGH, MTR, MTRR, SLC19A1, SHMT1, SNPs, homozygous
The wider genetic map in the final book
Chapters 3–4 and 11 of Outlive Your Toxic Genetics expand the discussion from MTHFR to folate handli…
…ame process. Dr. Purser discusses MTHFR alongside CBS, MTR, MTRR and SHMT1 because these genes participate in a broader metabolic network. A finding in one gene cannot tell you the activity of the entire network. Dr. Purser also introduces …
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