GGH
In the descriptionGGH encodes gamma-glutamyl hydrolase, which removes glutamate residues from folate compounds. This affects folate handling and helps explain why folate metabolism includes retention and processing as well as intake.
THE PURSER WELLNESS ENCYCLOPEDIA
Let’s explore “folate”
Explore this topic as a step-by-step interactive map.MTHFR, the citric acid cycle & ATP
A RELATED COURSEMethylation & B vitamins
Explore the course 4 chapters, at your pace
New to this subject? Start with this free introduction.Crash Course on MTHFR & Genetic Terminology
159 resources for your curiosity31 matching listings grouped; alternative sources stay available.
What’s searchable?MTHFD1
In the descriptionMTHFD1 helps move folate between forms used for different jobs in the body.
MTHFD1L
In the descriptionThe homocysteine chapters include MTHFD1L in the wider folate-related genetic map.
SHMT1
In the descriptionSHMT1 connects serine and glycine with folate chemistry.
Homocysteine and methylation
In the descriptionFollow Dr. Purser’s teaching on folate, B12, sulfur pathways and antioxidant support around homocysteine.
SLC19A1
In the descriptionEncodes the reduced folate carrier, a protein involved in transporting folates into cells.
MTHFS
In the descriptionMTHFS encodes an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR or a direct maker of methylfolate.
FOLR3
In the descriptionFOLR3 is the gene name for Folate Receptor 3. Learn what a specific result could mean and what to ask about it.
MTHFD1 & one-carbon metabolism
In the descriptionExplore rs2236225, rs1076991, folate-dependent one-carbon metabolism, nucleotide synthesis, homocysteine, and double homozygosity.
You eat something sweet.
In the descriptionYou eat something sweet. Your energy shoots up. Then suddenly you are exhausted, foggy, irritable, and reaching for something else to get you through the day. That cycle deserves a closer look. MTHFR variants can influence folate meta
What is MTHFR? What can YOU do about it?
In the descriptionMTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialized folates, B12 forms, and glutathione can bypass the blockages, and products like MTHFR Daily were designed specifically to fill these nutrient gaps so patients can restore energy and thrive.
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What Happens If You Have A Gene SNP?
In the descriptionGenetic SNPs are tiny changes in your DNA that can drastically affect how well your enzymes and proteins work. For example, being homozygous for MTHFR C677T leaves that enzyme functioning at only about 30% efficiency, which can drain your energy and impair folate processing. Similarly, errors in SOD genes reduce your body’s ability to neutralize free radicals. While we can’t change your genes, we can work around them by identifying these weaknesses and filling the gaps with targeted nutrition and supplementation—helping your body function closer to its full potential.
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