THE PURSER WELLNESS ENCYCLOPEDIA
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What’s searchable?HMGB1 normally has functions inside the cell nucleus. When released outside cells in particular settings, it can act as a damage-associated molecular pattern, or DAMP, participating in inflammatory signaling. Also called: A cellular protei…
IFNG encodes interferon gamma, a cytokine involved in cellular immune defense and activation of macrophages. It differs from the Th2 signals more often emphasized in allergic responses. Also called: Interferon gamma and macrophage activati…
IL10 encodes interleukin-10, a cytokine that can limit inflammatory responses and help prevent excessive immune-mediated tissue damage. Immune balance includes resolving a response as well as starting one. Also called: The immune system al…
…12B encodes the p40 subunit shared by IL-12 and IL-23. This makes it an intersection between immune pathways rather than a stand-alone measure of one cytokine. Also called: A shared component of two cytokines IL12B encodes the p40 subunit …
IL13 encodes interleukin-13, a cytokine involved in Th2 immune responses, mucus-related processes and tissue remodeling. It overlaps with some IL-4 functions but is not the same signal. Also called: Allergic signaling and tissue responses …
…ncodes a cytokine involved in the survival and activity of immune cells, including natural killer cells and memory CD8 T cells. Its receptor system includes IL15RA. Also called: Supporting immune-cell survival IL15 encodes a cytokine invol…
IL15RA encodes the alpha receptor component for IL-15. It helps present IL-15 to responding immune cells, supporting communication that is important for particular lymphocyte populations. Also called: Presenting IL-15 to responding cells I…
…ukin-16, a cytokine involved in attracting and influencing immune cells, including CD4-expressing cells. Its recruitment role helps separate it from other numbered interleukins. Also called: A cytokine involved in immune-cell traffic IL16 …
… a cytokine involved in defense at tissue barriers and inflammatory signaling. It belongs to the Th17 pathway, which is supported by signals including IL-23. Also called: Th17 signaling and persistent inflammation IL17A encodes interleukin…
IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP. Also called: An inflammatory signal that connects to int…
IL18R1 encodes a component of the receptor for IL-18. It works with an accessory component, IL18RAP, to support IL-18 signaling. Also called: The binding side of the IL-18 receptor IL18R1 encodes a component of the receptor for IL-18. It w…
…L18RAP encodes an accessory protein in the IL-18 receptor complex. The receptor needs coordinated components to translate an extracellular signal into a cellular response. Also called: The accessory component of IL-18 signaling IL18RAP enc…
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