Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.
Also called: Methylenetetrahydrofolate Reductase, C677T, A1298C…
Helps maintain the activity of methionine synthase, connecting B12-related chemistry with homocysteine metabolism.
Also called: Methionine Synthase Reductase
Keeping the remethylation system working
Dr. Purser teaches MTRR alongside MTR bec…
NOS3 encodes endothelial nitric oxide synthase, which helps blood vessels generate nitric oxide, a signal involved in vascular relaxation. This pathway is distinct from a blood pressure measurement or a diagnosis of vascular disease.
Also c…
NQO1 is the gene name for NAD(P)H Quinone Oxidoreductase 1. Learn what a specific result could mean and what to ask about it.
Also called: NAD(P)H Quinone Oxidoreductase 1
Quinone handling within the redox network
Dr. Purser includes NQO1 i…
NR3C2 encodes the mineralocorticoid receptor, which responds to hormones such as aldosterone and helps regulate salt and fluid balance. It is distinct from the NR3C1 glucocorticoid receptor.
Also called: Mineralocorticoid Receptor / Nuclear…
SERPINE1 makes PAI-1, a protein involved in breaking down blood clots. You may also see PAI4G used for this pathway.
Also called: PAI-1, PAI4G, Plasminogen Activator Inhibitor-1, Plasminogen Activator Inhibitor 1, 4G/5G Polymorphism
Balanci…
SHMT1 connects serine and glycine with folate chemistry.
Also called: Serine Hydroxymethyltransferase 1
Where amino acids meet folate
SHMT1 connects serine and glycine with folate pathways. That is one reason both nutrition and genetics can…
TNF encodes tumor necrosis factor, an immune-signaling protein involved in inflammation, host defense and regulation of cell survival. Its name should not be read as proof that a TNF result indicates cancer.
Also called: Tumor Necrosis Fact…
VDR encodes the vitamin D receptor, which helps regulate gene activity in response to active vitamin D. A receptor variant does not by itself mean receptors are absent or that the blood vitamin D level is low.
Also called: Vitamin D Recepto…
CCL11 encodes eotaxin-1, a chemokine best known for attracting eosinophils. Its receptor relationships connect it to allergic inflammation as well as broader research into immune signaling.
Also called:
Eotaxin-1 and eosinophil recruitment…
CCL2 encodes MCP-1, a chemokine that attracts monocytes toward sites of immune activity. Recruitment is a different task from the cytokines that activate those cells once they arrive.
Also called:
MCP-1: recruiting monocytes
CCL2 encodes M…
CCL4 encodes MIP-1 beta, a chemokine involved in attracting immune cells. It participates in a recruitment network that includes CCL2, CXCL8 and related chemokines.
Also called:
MIP-1 beta and overlapping recruitment signals
CCL4 encodes M…
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