… B12. The teaching distinction is between eating or supplementing a vitamin, transporting it, and using it in an enzyme reaction.
Putting the pieces together
TCN2 connects to how B12 is carried in the body. Your clinician may compare this r…
…: Tumor Necrosis Factor
TNF is an immune signal with many contexts
TNF encodes tumor necrosis factor, an immune-signaling protein involved in inflammation, host defense and regulation of cell survival. Its name should not be read as proof t…
…e activity in response to active vitamin D. A receptor variant does not by itself mean receptors are absent or that the blood vitamin D level is low.
Also called: Vitamin D Receptor, VDR FOK, VDR TAQ
Vitamin D levels and vitamin D response
…
…t matters to clotting and medication response. Certain variants can alter warfarin dose requirements, including increased sensitivity; they do not generally mean warfarin will not work. Anyone taking warfarin should discuss vitamin K produc…
How the Purser approach moves from a nutrient finding to priorities, a manageable plan and reassessment.
Also called:
From a laboratory flag to a useful plan
Start with your original CMA report: check its date, values, and the lab’s catego…
… Dr. Purser’s teaching on folate, B12, sulfur pathways and antioxidant support around homocysteine.
Also called:
Follow the branches around homocysteine
Homocysteine sits at a junction in the pathway. Dr. Purser’s teaching follows homocyst…
Separate the gene, variant, measured value and clinical interpretation—and learn which questions to bring to your visit.
Also called:
Keep the original result in view
Start with your original report: check the date, units, the lab’s range,…
…folate carrier, a protein involved in transporting folates into cells.
Also called: RFC1, reduced folate carrier, folate transport
Folate transport is part of the story
Dr. Purser’s folate map includes transport as well as conversion. SLC19…
…s tissue-nonspecific alkaline phosphatase, an enzyme important to bone and tooth mineralization and vitamin B6 metabolism. Persistently low alkaline phosphatase can deserve a different evaluation from a general nutrient deficiency.
Also cal…
…ct it to allergic inflammation as well as broader research into immune signaling.
Also called:
Eotaxin-1 and eosinophil recruitment
CCL11 encodes eotaxin-1, a chemokine best known for attracting eosinophils. Its receptor relationships conn…
…ttracts monocytes toward sites of immune activity. Recruitment is a different task from the cytokines that activate those cells once they arrive.
Also called:
MCP-1: recruiting monocytes
CCL2 encodes MCP-1, a chemokine that attracts monocy…
…hemokine cluster. The useful lesson is overlapping recruitment signals rather than a unique disease prediction from one marker. Closely related genes and nearby variants need careful naming and mapping.
A question to bring to your visit
Has…
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