THE PURSER WELLNESS ENCYCLOPEDIA

Let’s explore “TNFSF10 / TRAIL signaling”

A RELATED COURSEYour cytokine starting point

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Gene referenceSep 23, 2026

HMGB1

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HMGB1 normally has functions inside the cell nucleus. When released outside cells in particular settings, it can act as a damage-associated molecular pattern, or DAMP, participating in inflammatory signaling.

Gene referenceSep 23, 2026

IL17A

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IL17A encodes interleukin-17A, a cytokine involved in defense at tissue barriers and inflammatory signaling. It belongs to the Th17 pathway, which is supported by signals including IL-23.

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