Let’s explore “Folate, serum — lab reference”

DHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in cellular metabolism. This is one part of the folate system, distinct from MTHFR and folate transport into cells.

FOLH1 helps break down folate from food so it can be absorbed. This is different from the MTHFR step.

FOLR1 encodes folate receptor alpha, which helps cells take up folate and has an important role in folate transport at the brain’s barriers. Blood folate and folate availability in the nervous system are not identical measurements.

FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier.

GGH encodes gamma-glutamyl hydrolase, which removes glutamate residues from folate compounds. This affects folate handling and helps explain why folate metabolism includes retention and processing as well as intake.

MTHFD1 helps move folate between forms used for different jobs in the body.

The homocysteine chapters include MTHFD1L in the wider folate-related genetic map.

SHMT1 connects serine and glycine with folate chemistry.

Follow Dr. Purser’s teaching on folate, B12, sulfur pathways and antioxidant support around homocysteine.

Encodes the reduced folate carrier, a protein involved in transporting folates into cells.

MTHFS encodes an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR or a direct maker of methylfolate.

PURSER WELLNESSWild genetic facts I learned this week that could actually be deadlyA conversation with Dr. Purser

…urodedevelopmental conditions due to reduced SAM um and availability of neurotransmitter synthesis. So, um, so I saw a patient with Tourette's and they had this. I'm like, there may be a way around it even though she's a little older. Um, I…