…measured IL-6 concentration and a diagnosis of inflammatory disease are three different kinds of information. IL6R adds the receptor side of the story.
More from the teaching: Inflammation, energy and metabolic overlap
In Dr. Purser’s cours…
…lp distinguish mechanical problems from active inflammatory disease. A panel SNP cannot tell you that MMP3 is absent or diagnose arthritis or cancer.
A question to bring to your visit
Is my joint problem primarily mechanical, inflammatory o…
MTHFD1 helps move folate between forms used for different jobs in the body.
Also called: Methylenetetrahydrofolate Dehydrogenase 1
Folate has several working forms
Dr. Purser includes MTHFD1 among genes involved in folate interconversion. T…
The homocysteine chapters include MTHFD1L in the wider folate-related genetic map.
Also called: Methylenetetrahydrofolate Dehydrogenase 1-Like
A mitochondrial contribution to one-carbon metabolism
The homocysteine chapters include MTHFD1L i…
NR3C1 encodes the glucocorticoid receptor, which helps tissues respond to cortisol and glucocorticoid medicines. Receptor genetics and measured cortisol levels answer different questions.
Also called: Nuclear Receptor Subfamily 3 Group C Me…
PON1 is discussed in relation to how the body handles some compounds and protects certain fats.
Also called: Paraoxonase 1
A different part of antioxidant handling
PON1 appears in Dr. Purser’s redox and conversion teaching alongside GST and…
…ice should consider the actual response, cardiovascular and kidney risks, gastrointestinal history and other medicines.
A question to bring to your visit
What has my actual response to anti-inflammatory treatment been, and which risks shape…
SERPINE1 makes PAI-1, a protein involved in breaking down blood clots. You may also see PAI4G used for this pathway.
Also called: PAI-1, PAI4G, Plasminogen Activator Inhibitor-1, Plasminogen Activator Inhibitor 1, 4G/5G Polymorphism
Balanci…
SHMT1 connects serine and glycine with folate chemistry.
Also called: Serine Hydroxymethyltransferase 1
Where amino acids meet folate
SHMT1 connects serine and glycine with folate pathways. That is one reason both nutrition and genetics can…
SOD1 helps convert superoxide inside cells as part of the body’s antioxidant defenses.
Also called: Superoxide Dismutase 1
Superoxide defense in its own setting
Dr. Purser teaches SOD as one member of an antioxidant team. SOD1 works primari…
…proach does not replace evaluation of infection, autoimmune disease or another cause of inflammation, and the genotype does not determine a measured TNF level.
More from the teaching: Understanding inflammatory amplification
Dr. Purser disc…
…h supplementation to measured 25-hydroxyvitamin D, calcium, kidney context and the current product list. High-dose vitamin D should not be selected from a SNP alone. The familiar labels are BsmI for rs1544410, TaqI for rs731236 and FokI for…
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