CUBN
Some search terms matched…ongside B12 absorption, Intrinsic factor receptor activity, Methylation, Folate metabolism. These are topics to explore, not a diagnosis or a measurement of how the pathway works in your body.
Understanding a result
A gene name is only a st…
FOLR3
Some search terms matched…3 discussed alongside Folate transport, Placental function, Methylation, Folate metabolism, PCOS, Insulin/glucose regulation, Hormone metabolism. These are topics to explore, not a diagnosis or a measurement of how the pathway works in your…
DAOA / G72 (rs2391191)
Some search terms matched… AOC1, the gene involved in digestive histamine breakdown.
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Dr. Purser discusses rs2391191, also described as Arg30Lys, alongside glutamate signaling and research on mood and cognition. D-serine helps NMDA receptors respo…
Hailey-Hailey disease & cytokines
Some search terms matched…C1 gene and calcium handling are central to the condition.
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Dr. Purser connects acantholysis, friction, heat, infection, inflammatory cytokines, and oxidative stress. He discusses the antioxidant triad as an adjunctive qu…
HFE (H63D / rs1799945) & iron
Some search terms matched… is different from C282Y and from many other HFE variants.
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Dr. Purser distinguishes a genetic susceptibility from measured iron overload. He discusses ferritin, transferrin saturation, liver health, and the greater signi…
IL-15 & homozygosity
Some search terms matched…ributing to persistent immune activity in some conditions.
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Dr. Purser discusses IL-15 in relation to chronic inflammatory symptoms, muscle and joint tissues, and vitiligo recurrence. Carrying two identical alleles does n…
IL-1 beta / IL1B
Some search terms matched…participates in fever and the recruitment of immune cells.
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Dr. Purser connects IL-1β with gout, inflammatory pain, and other immune conditions. He discusses targeted IL-1 therapies and the separate role of glutathione, s…
IL-23R & liver health
Some search terms matched… and NASH appear alongside the newer terms MASLD and MASH.
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This teaching follows IL-23 receptor signaling into IL-17 activity, liver inflammation, and the cells involved in fibrosis. Glutathione, superoxide dismutase, an…
IL-6 & liver health
Some search terms matched… can progress to inflammation and scarring in some people.
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Dr. Purser discusses hepatic stellate cells, fibrosis, and the interaction of cytokines with reactive oxygen species. He follows the antioxidant partnership of g…
IL-6 & migraines
Some search terms matched…in a wider network rather than the only cause of migraine.
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His teaching connects cytokines, homocysteine, oxidative stress, and the trigeminal pain pathway. Conventional migraine discussions include triptans and CGRP-dir…
Low hemoglobin A1C: interpreting the result
Some search terms matched…r when red blood cells do not survive as long as expected.
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Dr. Purser discusses hemolysis, blood loss, transfusion, and other changes in red-cell turnover alongside true hypoglycemia. Kidney or liver conditions and certa…
MAO-A & MAO-B: combined variants
Some search terms matched…mitters, and the reaction also produces hydrogen peroxide.
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Dr. Purser discusses MAOA rs1137070, rs2072743, and rs6323 alongside MAOB rs1799836 and rs2283729. He connects monoamine processing with riboflavin-dependent FAD…
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